\"Systems Biology" by Edda Klipp et al. has now been transformed into a true textbook that is suitable for adoptions. It comes in a large format with an improved layout, professional artwork throughout, student friendly reading lists and a greatly improved companion website featuring all figures, a short exam prep version of the book and educational modeling programs. As in the current version, the text is written in an easily accessible style and includes numerous work examples and study questions in each chapter. The experienced author team around Edda Klipp works closely together to ensure a homogenous style and comprehensive coverage with no overlaps. A section on medical systems biology is now included. Systems biology is becoming an integral part of life science curricula and is geared towards biologists, engineers and computer scientists.