Clinicians and students at all levels and in all primary care disciplines will benefit from the clear, practical, evidence-based writing and recommendations that address the full spectrum of clinical problems encountered in the adult primary care practice. Whether it’s the answer to a screening, prevention, evaluation, or management question or a comprehensive approach to a complex condition, the reader will find a review of best evidence integrated with considerations of affordability, cost-effectiveness, convenience and patient preference. Chapters present actionable, scientifically validated guidance that allows physicians to go beyond standard consensus guidelines and provide highly personalized care. Special consideration is given to team-based approaches of primary care delivery, recognizing its increasing importance to achieving high levels of practice performance.