Although textbooks on the physics of condensed matter consider non-covalent interactions in detail, their application for analysis of protein properties is often poorly presented or omitted. On the other hand, books on biochemistry, molecular modeling or molecular simulation introduce these interactions in the context of the corresponding topic, which sometimes results in superficial explanations of their nature. This book succeeds in uniting comprehensive considerations of non-covalent interactions with the specificity of their application in protein sciences.This second edition includes new chapters on intrinsically disordered proteins, microcalorimetry of proteins, cold denaturation, thermodynamic stability and thermal adaptability of proteins. The ideal aid for students of physics or chemistry, with interests in biology and biophysics, the book can also be useful for students of biology, biochemistry, or biomedicine who want to extend their knowledge of how protein properties are described at the molecular level.

Professor Andrey Karshikoff is formerly Director of the Institute of Molecular Biology at the Bulgarian Academy of Sciences. He holds a PhD in Biophysics from Sofia University, Bulgaria. After the political changes in his country he was able to move to Max-Planck Institute for Biochemistry, Germany, where he spent several years as Alexander-von-Humboldt and Max-Planck Fellow. He continued his research as Associate Professor at Karolinska Institute, Sweden. His research was in the field of structure-function relationships in proteins. He has 20 years of experience in teaching undergraduate and graduate students. He has published over 70 papers in reputed journals such as Journal of Molecular Biology, Biochemistry, Protein Science, Journal of Chemical Physics, Trends in Biochemical Sciences, and others.