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nobuy
CLCO6
LanguageENG
PublishYear2009
publishCompany Wiley
EISBN 9780470749715
PISBN 9780470319611
edition 1
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  • Contents
Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create tailor-made peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins for Biopharmaceutical Applications   comprehensively presents the central topics within the design of peptides and small proteins, especially with the goal of biopharmaceutical applications. The book starts with an outline of computational methods, then moves on to cyclic peptides, which are often important in the development of peptide drug candidates, provides an overview of peptidomimetics, carbohydrates in the design of peptides and proteins, de novo design of proteins, and finally, as a key example, describes the design of new insulin variants. Design of Peptides and Proteins for Biopharmaceutical Applications   presents the state-of-the-art of this exciting new approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry

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